Dissolution Enhancement of Clarithromycin Using Ternary Cyclodextrin Complexation

Dissolution Enhancement of Clarithromycin Using Ternary Cyclodextrin Complexation


Uma Mulimani, Barkha Goswami, Bharat Rughwani


Abstract

The research work presented is new and never been done earlier. Clarithromycin, a semi-synthetic macrolide antibiotic derived from erythromycin having low solubility and high permeability falling in class-II of Biopharmaceutical Classification System (BCS). The drug is practically insoluble in water exhibiting dissolution rate limited absorption. The objective of the research work increasing in the solubility, release properties of Clarithromycin and improve the bioavailability of Clarithromycin using ternary inclusion complex with Beta Cyclodextrin. The research work includes developing a multi-component system comprising of macrolide: Clarithromycin, Beta-cyclodextrin and a polymer Soluplus to attain enhanced solubility of Clarithromycin. The inclusion complexes were prepared by slurry evaporation and kneading method using different proportions of B-CD'S and Soluplus. The complexes were characterized by solubility, drug content uniformity, dissolution rate, similarity factor analysis and by HPLC. The ternary inclusion complexes prepared by the kneading method were evaluated for solubility enhancement and improved dissolution rate. Formulations with a Soluplus concentration of 20% w/w of drug content and solvent ratio of 70:30 (water: ethanol) showed more than 80% of drug release at the end of one hour.


Keywords

Clarithromycin (CLM), Beta Cyclodextrin (BCD), Soluplus (SOL), Slurry Evaporation (SE), Kneading method (KN), HPLC


Cite This Article

Mulimani, U., Goswami, B., Rughwani, B. (2018). Dissolution Enhancement of Clarithromycin Using Ternary Cyclodextrin Complexation. International Journal for Pharmaceutical Research Scholars, 7(3); 18-29.

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