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Clinical Efficacy of Misoprostol in Second Trimester Abortion

Received On: 05/03/2014
Accepted On: 10/03/2014


Shah, A. C., Shah, S., Modi, A., Modi, R.

Author's Affiliation


Study was conducted from February, 2013 to April, 2013 at Sheth L.G. Hospital, AMC MET Medical College, Ahmedabad, Gujarat. A total of 50 patients, at 13-28 weeks of gestation, requiring termination of pregnancy were included in study protocol. Major indications for termination of pregnancy were intrauterine death of fetus, severe preclamsia and congenital anomaly. Each woman received first dose of 400 μg of misoprostol vaginally and were repeated every 4 hours as per need till induction of abortion. Abortion was seen in 13(26%) patients with induction to delivery period of less than 12 hour. Out of 50 women, 20 (40%) have been aborted in between 12 to 16 hours of drug administration. Whereas in 10(%) women, termination of pregnancy was found in between 16 to 20 hours. Though in 7(14%) patients, pregnancy was terminated after 20 hours. It was found complete and incomplete abortion in 43(86%) and 7(14%) cases, respectively. Observed side effects included G.I. disturbances and fever in 10(20%) and 15(30%) cases, respectively. Overall per vaginal administration of misoprostol was found clinically safe , efficacious and a cost effective for induction of second trimester abortion.


Efficacy, Misoprostol, Abortion, Second-Trimester

Cite This Article

Shah, A. C., Shah, S., Modi, A., & Modi, R. (2014). Clinical Efficacy of Misoprostol in Second Trimester Abortion. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 477-480.

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