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Formulation and Evaluation of Sustained Release Pellets of Theophylline by Spray Drying Technique

Received On: 01/09/2014
Accepted On: 06/09/2014


Chemate, S. Z., Patil, S. V.

Author's Affiliation


The present study was aimed to Theophylline sustained release pellets for the treatment of Asthma. The biological half life of Theophylline is 3 hour. Hence it requires twice or three times a day dosing. Theophylline sustained release pellets sustained the half life to 8 hour i.e. shows increase in half life means reduce dosing frequency. A total of 6 formulation containing drug: polymer complexes prepared by Spray drying method have show better physicochemical properties. HPMC K4M and Ethyl cellulose as binding solution was optimized as sustained release polymer for pellet of Theophylline. The pellets were evaluated for parameters such as bulk density, tapped density, angle of repose, compressibility index and Hausner’s ratio. Evaluation tests of pellets such as general appearance, Scanning electron microscopy and in vitro release studies were performed. Out of 6 formulations, the formulation batch F4 shows more drug release i.e. upto 96.426±0.32%. Hence it can be concluded that formulation F4 containing HPMC K4M and Ethyl cellulose are suitable for development of Sustained release pellets of Theophylline.


Hydroxy Propyl Methyl Cellulose, Theophylline

Cite This Article

Chemate, S. Z., & Patil, S. V. (2014). Formulation and Evaluation of Sustained Release Pellets of Theophylline by Spray Drying Technique. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 251-258.

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