Received On: 26/10/2014
Accepted On: 30/10/2014
Anusha, P., Rao, J. V.
The main objective of the medicinal chemistry is to synthesize the compounds that show promising activity as therapeutic agents with lower toxicity. Benzoxazole derivatives are very useful compounds with well known biological activity. In the current research work, the title compounds 2-mercapto-N-(substituted arylidine) benzoxazole-5-carbohydrazide derivatives were synthesized by the reaction of Schiff bases of 2-mercapto benzoxazole-5-carbohydrazide with appropriate aromatic aldehydes. The synthesized compounds were confirmed structurally by means of IR, 1HNMR, Mass spectral analysis. Further, the synthesized compounds (VIa-VIf) were screened for anti-inflammatory activity by using carrageenan – induced rat paw edema method. The results showed that, compound VId was significantly (p<0.001) reduced the inflammation there by showed a promising anti-inflammatory activity; whereas the compounds i.e., VIa, VIc, VIe, VIb moderately reduced the inflammation. Only one compound VIf showed very poor anti-inflammatory activity after one hour of administration.
Benzoxazole Derivatives, IR, 1HNMR, Mass Spectroscopy, Anti-inflammatory Activity
Cite This Article
Anusha, P., & Rao, J. V. (2014). Synthesis and Biological Evaluation of Benzoxazole Derivatives as New Anti-Inflammatory Agents. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 53-58.