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Anti-Diabetic Activity of Polyphyto Combination in Alloxan induced Diabetic Rats


Received On: 27/10/2014
Accepted On: 01/11/2014


Author(s)

Nautiyal, A., Satheesh, M. N. V., Bhattacharya, S., Uniyal, S. N.


Author's Affiliation


Abstract

Diabetes mellitus is a metabolic disorder of carbohydrate, protein and fat which are characterized by hyperglycemia, polyuria, polydipsia, and polyphagia which is deficient insulin production or ineffectiveness in insulin actions. There are two major types of diabetes Type 1, type 2, gestational and other specific type’s secondary diabetes). The present study was aimed to evaluate the anti diabetic potency of polyphyto combination (FD18) on the blood glucose level in alloxan induced diabetic rats. Diabetic Albino wistar strain rats were treated with standard drug glibenclamide and test drug FD18 at 100mg. Hypoglycemic effect was determined in the rats and the efficacy of the test drug was compared to the standard drug Glibenclamide. FD18 was orally administered for 14days in alloxan induced diabetic rats. At the end of the study duration blood glucose level and body weight were statistically analyzed. Based on these results of the study this poly phyto combination produced a significant reduction in blood glucose levels and slight increase in the body weight when compared with diabetic control rats. And hence the present research work proved that the polyphyto combination possess hypoglycemic effect.


Keywords

Diabetes Mellitus, Alloxan, Glibenclamide, Polyphyto Combination, Blood Glucose Level, Body Weight, Anti-Diabetic Activity

Cite This Article

Nautiyal, A., Satheesh, M. N. V., Bhattacharya, S., & Uniyal, S. N. (2014). Anti-Diabetic Activity of Polyphyto Combination in Alloxan induced Diabetic Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 59-63.


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