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Novel Poly(Vinyl caprolactum-co-Sodiumacrylate) Microspheres for Controlled Release of 5-Fluorouracil


Received On: 09/10/2018
Accepted On: 15/10/2018


Author(s)

C. S. RAJESH, J. N. Sunitha, K. Sheshappa Rai


Author's Affiliation

Department of studies in polymer science, University of Mysore, Mysore, Karnataka, India.


Abstract

Novel poly(vinyl caprolactum-co-sodiumacrylate) copolymeric microspheres crosslinked with N,N-methylene bisacrylamide have been prepared by free radical emulsion polymerization using varying amounts of Sodiumacrylate (SA), vinyl caprolactum (VC) and N,N-methylene bisacrylamide (NNMBA). 5-Fluorouracil was loaded into these microspheres during in situ polymerization. The microspheres have been characterized by differential scanning calorimetry (DSC) and x-ray diffractometry (x-RD) to understand the drug dispersion in the microspheres. Scanning electron microscopy (SEM) was used to assess the surface morphology of particles prepared. In vitro release of 5-fluorouracil was studied by varying of copolymer composition, amount of crosslinking agent and amount of 5-fluorouracil in the microspheres. Microspheres with different copolymer compositions have been prepared in yields of 80-85 %. DSC indicated the uniform distribution of 5-fluorouracil particles in the microspheres, whereas SEM suggested their spherical structure with slight rough surfaces. The in vitro drug release indicated that particle size and release kinetics depend upon copolymer composition, amount of crosslinking agent used and amount of 5-fluorouracil present in the microspheres.


Keywords

N-vinylcaprolactam, Sodiumacrylate, 5-Fluorouracil, Controlled Drug delivery

Cite This Article

Rajesh, C. S., Suntiha, J. N., Ramesh, V. B., Rai, K. S. (2018). Novel Poly(Vinyl caprolactam-co-Sodium acrylate) Microspheres for Controlled Release of 5-Fluorouracil. International Journal for Pharmaceutical Research Scholars, 7(4), 10-21. http://dx.doi.org/10.31638/IJPRS.V7.I4.00004


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