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Application of In Situ Generated Chiral Oxazaborolidine Catalyst for the Enantioselective Reduction of Prochiral Ketones


Received On: 08/12/2018
Accepted On: 20/12/2018


Author(s)

Inamdar Murad Ismail


Author's Affiliation

1Sun Pharmaceutical Industries Limited, Sarhaul, Sector 18, Gurugram, Haryana, 122015, India. 2Discipline of Chemistry, School of Sciences, IGNOU, New Delhi, 110068, India.


Abstract

In situ synthesis of chiral oxazaborolidine catalyst by using (1S, 2R)-(-)-cis-1-amino-2-indanol, tetrabutylammonium borohydride and methyl iodide is described. Various borane reduction systems have been studied. Application of (1S, 2R)-(-)-cis-1-amino-2-indanol along with tetrabutylammonium borohydride and methyl iodide to reduce prochiral ketones to the corresponding alcohols with enantiomeric excess up to 96 % is reported. Graphical Abstract Abstract


Keywords

Enantioselective ketone reduction, In situ oxazaborolidine catalyst

Cite This Article

Ismail, I. M., Prasad, M., Kumar, L. S. (2018). Application of In Situ Generated Chiral Oxazaborolidine Catalyst for the Enantioselective Reduction of Prochiral Ketones. International Journal for Pharmaceutical Research Scholars, 7(4), 31-39. http://dx.doi.org/10.31638/IJPRS.V7.I4.00008


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