Received On: 19/11/2018
Accepted On: 30/11/2018
Umesh Prabhakar Joshi, Rajendra Dayaram Wagh
DCS's A. R. A. College of Pharmacy, Mumbai-Agra Road, Nagaon, Dhule, Maharashtra, India, 424006
The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs it leads to the evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in-vitro experiments were conducted to determine the possible anthelmintic effects of crude Methanolic, aqueous and hydroalcoholic extracts of the bark of Ehretia laevis on eggs and adult Pheritima posthuma and Ascardia galli. Three concentrations (10, 25, 50 mg/ml) of Methanolic, aqueous and hydroalcoholic extracts of plant Ehretia laevis were studied in activity which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Piperazine citrate in same concentration as those of extract was included as standard reference and normal saline water with 1% CMC as control. All the extracts exhibited significant anthelmintic activity at a concentration of 50 mg/ml. Peak activity was exhibited by the methanolic extract at a concentration of 50 mg/ml. The overall findings of the present study have shown Ehretia laevis contain possible anthelmintic compounds and further evaluation of these plants should be carried out. The ethnomedicinal claim of anthelmintic activity of this plant is genuine.
Anthelmintic activity, Ehretia laevis, Pheritima posthuma, Ascardia galli, Piperazine citrate, Helminthiasis
Cite This Article
Joshi, U. P., Wagh, R. D. (2018). In-Vitro Anthelmintic Activity of Ehretia laevis bark On Indian Adult Earthworm. International Journal for Pharmaceutical Research Scholars, 7(4), 22-30. http://dx.doi.org/10.31638/IJPRS.V7.I4.00012