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Special Approach to Linger Residence Period of Drug Formulations for Enhancement of Bioavailability and Therapeutic Activity Based on Mucoadhesive Polymers


Received On: 20/10/2019
Accepted On: 29/10/2019


Author(s)

Basudev Sahana, Kuhu Bhaduri


Author's Affiliation

Department of Pharmaceutics, Institute of Pharmacy, Jalpaiguri, Dept. of Health and Family Welfare, Govt. of West Bengal, Affiliated to The West Bengal University of Health Sciences, P.O. & Dist. - Jalpaiguri, West Bengal, PIN-735101, India


Abstract

Drug formulations can be placed specially using polymers interacting with mucus layer in the body cavities or gastrointestinal tract wall. Spatial placement of the drug formulations made of mucoadhesive polymers fulfill the goal for providing an effective amount of drug to the proper site in the body to promptly achieve action and then maintain the desired drug concentration for a long time. The mucoadhesive polymers interact with the mucus membrane that lines organs and body cavities such as mouth, gut, rectum, genital area, nose, and eye lid. Anatomical differences of the mucus membrane at varying body locations, their mucoadhesion phenomenon and as route of administration of various formulations based on polymers interacting on mucus have been studied in this article. The special aim of the current work is to study various natural polymers obtained from edible plants and their utilization in controlled release mucoadhesive dosage forms design and development. Mucoadhesive polymers can interact with the mucin of our body cavities or gastro-intestinal mucus layer and enhance the residence period of time of the dosage forms in particular site of absorption. Prolong residence time may linger the absorption and enhance the bioavailability of drug as well as the action of drug. The use of edible polymers can minimize the health hazards and uplift the health care system in near future.


Keywords

Spatial placement, mucoadhesion, edible plant’s polymers, linger absorption

Cite This Article

Basudev Sahana, Kuhu Bhaduri (2019). Special Approach to Linger Residence Period of Drug Formulations for Enhancement of Bioavailability and Therapeutic Activity Based on Mucoadhesive Polymers. International Journal for Pharmaceutical Research Scholars, 8(4); 1-18.


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