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Hypolipidemic Activity of Protocatechuic Acid in Atherogenic Diet Induced Hyperlipidemic Rats

Received On: 20/02/2012
Accepted On: 27/02/2012


Borate, A.R., Suralkar, A.A., Deshpande, A.D., Malusare, P.V., Bangale, P.A.

Author's Affiliation


Hyperlipidemia is an abnormally high level of fatty substances called lipids, largely cholesterol and triglycerides, in the blood. The present study was designed to investigate the hypolipidemic effects of Protocatechuic acid in atherogenic diet induced hyperlipidemia. In an atherogenic diet-induced hyperlipidemic model, the rats receiving treatment of Protocatechuic acid at the dose of 25 and 50 mg/kg showed a significant reduction in total cholesterol, triglyceride, total protein and elevation in high-density lipoprotein cholesterol. Hence by considering the effects observed in this model, it has been suggested that Protocatechuic acid was found to possess significant hypolipidemic activity, this may be due to its effect on increasing the metabolism of the cholesterol by activating lipoprotein lipase or by increasing reverse cholesterol transport.


Atherogenic diet, Protocatechuic acid, Cholesterol, Hyperlipidemia, Hypolipidemic activity

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