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Effect of DMF on Molecular Interactions of Triazole Derivative at Different Temperatures

Received On: 01/04/2012
Accepted On: 05/04/2012


Rajkotia, K.M.

Author's Affiliation


The present work describes the synthesis, thermo-acoustical parameters and thermal analysis of 5-(3-methoxyphenyl)-1-phenyl-2-((m-tolylamino)methyl)-1H-1,2,4-triazole-3(2H)-thione (T4a). The viscosity (η), density (ρ) and ultrasonic sound velocity (U) of N,N-dimethyl formamide (DMF) and solutions of T4a (0.1-0.01 M) were investigated at three different temperature (303, 308 and 313) K and atmospheric pressure. Some acoustical parameters such as intermolecular free path length (Lf), adiabatic compressibility (κs), Rao’s molar sound function (Rm), internal pressure (π), Van der Waals constant (b), free volume (Vf) and Gibbs free energy of the decomposition (DG#), solvation number (Sn), enthalpy of activation (DH#), pre-exponential factor (A) and entropy of activation (DS#) were calculated. The results obtained were interpreted in terms of solute-solvent and solute-solute interactions.


Thermo-acoustical parameter, Physico-chemical study, Kinetic parameter, Molecular interaction

Cite This Article

Rajkotia, K. M. (2012). Effect of DMF on Molecular Interactions of Triazole Derivative at Different Temperatures, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 19-25.

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