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Formulation and Evaluation of Floating Matrix Tablet of Ranitidine HCl

Received On: 12/05/2012
Accepted On: 16/05/2012


Ravat, H.D., Patel, J.G., Patel, K.N., Patel, B.A., Patel, P.A.

Author's Affiliation


Ranitidine HCl is used for the H2 receptor antagonist. It is an absorption window limited drug, whose solubility decreases with increase in the pH and has a short half life of 2-3 h. Therefore the present investigation is concerned with the development of the floating matrix tablets, which after oral administration were designed to prolong the gastric residence time and thus to increase the bioavailability of the drug and its half life. Ranitidine HCl showed maximum absorption at wavelength 324 nm in 0.1N HCl. Drug-polymer compatibility studies by DSC give conformation about their purity and showed no interaction between drug and selected polymers. Various formulations were developed by using release rate controlling and gel forming polymers like HPMC K4 M, and Polyethylene oxide WSR 303 in single by direct compression method with the incorporation of sodium bicarbonate as gas generating agent. All the formulations had floating lag time below 4 minutes and constantly floated on dissolution medium for more than 12 h. Swelling studies indicated significant water uptake and contributed in drug release. From all the developed formulations, batch F5 and F6 prolonged the drug release for longer period of time, they were nominated as best formulations. The best formulations followed power law kinetics while the drug release mechanism was found to be diffusion through and polymer relaxation. The best formulations were found to be stable during stability studies for one month. Thus, best formulations satisfied physico-chemical parameters, floating time, swelling index and in vitro drug release profile requirements for a floating drug delivery system.


Ranitidine HCl, Floating Drug Delivery System, Floating Matrix tablet

Cite This Article

Ravat, H.D., Patel, J.G., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Evaluation of Floating Matrix Tablet of Ranitidine HCl, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 521-532.

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