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Formulation and Evaluation of Floating Tablet of Amoxicillin Trihydrate


Received On: 12/05/2012
Accepted On: 16/05/2012


Author(s)

Yadav, V.T., Jayswal, B.D., Patel, K.N., Patel, B.A., Patel, P.A.


Author's Affiliation


Abstract

The present investigation concerns the design and evaluation of floating tablets of Amoxicillin trihydrate, which after oral administration, are designed to prolonged the gastric residence time and to obtain site-specific drug delivery for the stomach and increased drug bioavailability. Amoxicillin is a Semisynthetic antibiotic, belonging Beta-lactum family, which is effective for bacterial treatment, especially for helicobacter pylori infection. The dosage form was designed by using HPMC K100M, HPMC K15M and HPMC K4M polymers as gelling agents, sodium bicarbonate as gas-generating agent and other excipients. The interaction between drug and excipients in prepared floating tablets were studied by differential scanning calorimetry (DSC) and FT-IR. Floating tablets prepared by direct compression technique. The prepared floating tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, in-vitro floating studies, in-vitro drug release and short term stability studies.. The floating properties and drug release characteristics were determined for the prepared tablets in 0.1 N HCl and water dissolution media. Dissolution Profile was compared with dissolution profile of marketed tablet. The data obtained from in-vitro dissolution studies were fitted in different models. Final optimized formulation batch F10 released 93.02% and 73.02% drug in 0.1N HCl and water respectively.


Keywords

Amoxicillin trihydrate, Floating tablet, Hydroxy Propyl Methyl Cellulose, In-vitro floating study

Cite This Article

Yadav, V.T., Jayswal, B.D., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Evaluation of Floating Tablet of Amoxicillin Trihydrate, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 306-322.


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