Received On: 12/05/2012
Accepted On: 16/05/2012
Patel, J.G., Ravat, H.D., Patel, K.N., Patel, B.A., Patel, P.A.
The objective of the present work was to formulate and evaluate Mouth dissolving film of Domperidone. Domperidone is ideally suited for treatment of emesis. Mouth dissolving film of Domperidone is helpful in the vomiting during journey. Mouth dissolving films were prepared by Solvent casting technique and it is In vitro performance was evaluated by the usual pharmacopoeial and unofficial tests. The major advantage of the preparation technique includes fewer operation units, better content uniformity. The Mouth dissolving film formed was additionally found to be disintegrated within 1 min. The ratio of components in the Aqueous phase affected the thickness, drug content, tensile strength, percentage elongation, folding endurance, and release profile of Mouth dissolving film and the best results were obtained at the PVA(200 mg) and Glycerin(30 mg) The optimized formulation consists of batch of F2.Due to low PVA content it has optimum tensile strength and thickness. The developed mouth dissolving film of Domperidone might be clinically used for fast release of drug in mouth, for better drug utilization and improved patient compliance.
Domperidone, Solvent casting, Poly vinyl alcohol, Glycerin, Tensile strength
Cite This Article
Patel, J.G., Ravat, H.D., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Evaluation of Mouth Dissolving Film of Domperidone, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 244-253 .