Received On: 11/05/2012
Accepted On: 16/05/2012
Mohammed, R., Abullais, U., Patil, T.P., Patil, S.B.
Aim of present study was to investigate the analgesic activity of the leaves extracts of Achyranthus aspera linn. The leaves of drug is converted in uniform particle size and extracted by using Petroleum ether (60-800 c), Benzene, Chloroform, Ethyl acetate, n-Butanol, and Ethanol solvents. Then TLC and column chromatography is performing for isolation of active principle. This active principle is further carryout analgesic activity by Tail flick method and Writhing test method with the help of Aspirin (150 mg/kg) as standard drug. In Tail Flick Method the Ethanol extract showed good significant increase in reaction time as compared to pretreatment reaction time, where as n-Butanol, Chloroform, and Pet- ether extract, showed significant increase in reaction time, when compared to pretreatment reaction time However, Benzene and Ethyl acetate extract showed less significant increase in pretreatment reaction time. In Writhing Test Method the Ethanol extract showed good significant decrease in abdominal writhes as compared to standard group, where as n-Butanol extract, Ethyl acetate extract, Chloroform extract, Benzene extract, showed significant decrease in abdominal writhes, However, Pet-ether extract and Benzene extract failed to decrease in abdominal writhes when compared to standard group.
Achyranthus aspera, Analgesic activity, Column, Pretreatment, Aspirin
Cite This Article
Mohammed, R., Abullais, U., Patil, T.P., Patil, S.B. (2012). Pharmacognostical and Analgesic Activity of Various Leaves Extracts of Achyranthus Aspera Linn, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 79-91.