Home Abstract

Design and Development of Transdermal Therapeutic System of Carvedilol Using Combination of Natural and Synthetic Polymers

Received On: 05/04/2012
Accepted On: 09/04/2012


Patel, D.B., Patel, M.M., Patel, N.J.

Author's Affiliation


The present study was mainly focused on investigating the influence of concentration and combination of HPMC K4M, Carbopol 934P and Chitosan on physical characterization and drug release behavior of carvedilol transdermal films prepared by the solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by differential scanning calorimetry and infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. The prepared films were evaluated for physicochemical characteristics like weight variation, thickness, folding endurance, tensile strength, percentage moisture uptake, water vapor transmission rate, percentage flatness and in vitro permeation study. In vitro permeation studies were performed by using Franz diffusion cells. The drug release profiles of selected formulations were subjected to kinetic treatment using zero order, first order, Higuchi and korsmeyer’s peppas kinetic models. The results followed Higuchi kinetics (r2=0.951−0.995) and the mechanism of release was diffusion mediated. Based on physicochemical and in vitro permeation studies, transdermal film prepared by combination of HPMC K4M and Chitosan with ratio 3:1 selected as optimized formulation shows the drug release more than 24 hours with good flexibility and stability at 250C. The developed transdermal film increases the efficacy of carvedilol for the treatment of hypertension.


Transdermal, carvedilol, Optimization, Carbopol934P, Chitosan, HPMCK4M, differential scanning calorimetry, Fourier transfer infrared spectroscopy

Cite This Article

Patel, D.B., Patel, M.M., Patel, N.J. (2012). Design and Development of Transdermal Therapeutic System of Carvedilol Using Combination of Natural and Synthetic Polymers, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 35-44.

Recent Articles

Get FREE Updates for Upcoming
Pharma News, Jobs & Conferences

You have successfully subscribed to the newsletter

There was an error while trying to send your request. Please try again.

IJPRS will use the information you provide on this form to be in touch with you and to provide updates and marketing.