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Design, synthesis and biological evaluation of hydrazones of 2-phenyl imidazo[1,2-a]pyridines


Received On: 01/08/2017
Accepted On: 09/08/2017


Author(s)

Neeraj, P., Jayshri, P.


Author's Affiliation


Abstract

The phenyl hydrazones of 2-phenyl-imidazo[1,2-a]pyridines (7a-l) were prepared by the condensation of 2-phenyl-3-formyl-imidazo[1,2-a]pyridines 5 with phenyl hydrazines 6 in ethanol. The compounds were characterized by IR, 1H NMR and Mass spectral analysis. All the synthesized compounds were subjected for anti-inflammatory screening using protein denaturation assay and antioxidant screening. Most of the compounds were found to be potent anti-inflammatory and antioxidant agents. Compounds 7k, 7j, 7h and 7g were found to possess significant anti-inflammatory and antioxidant potential.


Keywords

Imidazo[1,2-a]pyridine, Hydrazone, Anti-inflammatory, Antioxidant

Cite This Article

Neeraj, P., Jayshri, P. (2017). Design, synthesis and biological evaluation of hydrazones of 2-phenyl imidazo[1,2-a]pyridines. International Journal for Pharmaceutical Research Scholars (IJPRS)6(3), 19 - 27.


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