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Development of UV Spectrophotometric Method for Estimation of Rivastigmine in Pharmaceutical Dosage Form


Received On: 23/11/2017
Accepted On: 28/02/2018


Author(s)

Kulkarni, A.S., Chandrashekhar, V.B., Amol, N.J.


Author's Affiliation


Abstract

In this present research work we have developed a validated UV spectrometric method for estimation of Rivastigmine in pure and pharmaceutical dosage form. The developed method is accurate, cost effective for the estimation of Rivastigmine in pure and pharmaceutical dosage form. Based on measurement of absorption of UV light, the spectra of Rivastigmine in water + methanol (9:1) as a solvent show maximum absorption wavelength (λmax) at 221nm. The calibration curve was plotted over the concentration range from 10 - 90 μg/ml of Rivastigmine with correlation coefficient 0.999. Validation was performed as per ICH Q2 guidelines for linearity, precision and recovery. This method has good reproducibility with % RSD less than one. The limit of detection (LOD) & limit of quantification (LOQ) were found to be 0.501 & 1.52 respectively by simple UV spectroscopy. Thus, this proposed validated method can successfully apply for estimation of Rivastigmine in quality control, routine analytical work in pharmaceutical dosage forms.


Keywords

Rivastigmine, Spectroscopic method, ICH Q2 guidelines

Cite This Article

Kulkarni, A.S., Chandrashekhar, V.B., Amol, N.J. (2018). Development of UV Spectrophotometric Method for Estimation of Rivastigmine in Pharmaceutical Dosage Form. International Journal for Pharmaceutical Research Scholars (IJPRS), 6(4), 59-64.


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