Received On: 14/04/2016
Accepted On: 22/04/2016
Bhor, R.J., Kunkulol, R.R.
Chromones derivatives and pyrazol derivatives were synthesized and screened for antibacterial activity. Some chromones and Pyrazol derivatives like 6-chloro-7-methyl-2-(pentafluorophenyl)-4H-chromen-4-one, 4-chloro-5-methyl-2-[5-(pentafluorophenyl)-1H-pyrazol-3-yl] phenol were synthesized by a sequence of reactions starting from 2-acetyl-4-chloro-5-methylphenyl pentafluorobenzoate, and were mentioned in scheme 1. The antibacterial activities of Chromones derivatives, Pyrazole derivatives were tested by the disc diffusion method by using Mueller Hinton Agar (M173) medium against various microorganisms such as Gram positive Staphylococcus aureus, Gram negative Escherichia coli, and Pseudomonas aeruginosa. Gentamycin at 100μg/ml were used as standard drugs for antibacterial activities. Characterization of the compounds was performed by IR, 1H NMR and Mass spectrum. The compounds bearing nitro and oxygen groups have shown prominent activity when compared to compounds without these groups.
Cite This Article
Bhor, R.J., Kunkulol, R.R. (2016). Synthesis and In-Vitro Antibacterial Activity of 2-Acetyl-4-Chloro-5-Methylphenyl Pentafluorobenzoate Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 46-54.