Received On: 30/04/2016
Accepted On: 07/05/2016
Rajput, A.P., Patil, S.A.
Esters of 2-(3, 4-dihydro-3-oxo-2H-benzo[b] [1, 4] thiazin-2-yl) acetic acid are synthesized and evaluated for their antimicrobial activity in vivo. All compounds are characterized by spectroscopic techniques such as FTIR, H1 NMR, C13 NMR and Mass. Molecular docking of these compounds is carried out in silico. The Molecular docking study provides detailed information about the nature and reactivity of the compounds. This helps to judge the biological activity of compounds using computer softwares. Molecular docking of these compounds is done with alpha amylase enzyme responsible for microbial attack. The result shows that all these esters are excellent inhibitors of alpha amylase.
2-(3, 4-Dihydro-3-oxo-2H-Benzo[b][1,4]Thiazin-2-yl)Acetic Acid, Antimicrobial, Docking
Cite This Article
Rajput, A.P., Patil, S.A. (2016). Synthesis, Molecular Docking and Antimicrobial Activity of 2-(3, 4-dihydro-3-oxo-2H-benzo [b] [1, 4] thiazin-2-yl) acetic acid Esters, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 97-106.