Home Abstract

Formulations and Evaluations of Sitopaladi Churna Pellets by Pelletization Technique to Improve Patient Compliance

Received On: 20/09/2016
Accepted On: 27/09/2016


Rodagi, M. S.

Author's Affiliation


The aim of this research work was conversion of Sitopaladi churnas into stable, palatable and patient acceptable pellets to swallow conveniently by direct pelletization techniques using disc pelletizer. In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system. It has good advantage over the conventional dosage form. Pelletization technique help in the formation of pellets having a diameter 0.5 -1.5 mm. The Sitopaladi pellets are prepared by using seven different binding agents such as Avicel, PVPK30, Methyl cellulose (MC), Hydroxyl Propyl Methyl Cellulose (HPMC), starch granules, calcium carbonate and microcrystalline cellulose (MCC). Simultaneously Crosscarmellose sodium was used as disintegrating agent. Propyl and Methyl parabens served as preservatives. Magnesium stearate and talc are used as lubricants. Mannitol is a cooling agent. Aerosil functions as anticaking agent which can stabilize the formulation. The Sitopaladi churna pellet formulation S1-S7 were optimized on the basis of acceptable flow properties of pellets. Developed  Sitopaladi churna pellets were tested for post preparation evaluation such as, Carrs index, Angle of Repose, Tapped Bulk density, swelling properties, friability, Disintegration test and particle size distribution were carried, hence S1, S3, S4, S5, S7 formulations showed better particle size distribution compare to other formulations due to drug release kinetics of these formulations are good. S6 formulation showed increase the degree of swelling due to its composition of CaCO3 it acts as a gas evolving disintegrant reacts with the 0.1N HCl used as media for the evaluation of swelling property. Hence increase in the pH of the swelling media due to rapid absorption of water and swell leading to an enormous increase in volume of pellets. The disintegration time of all the formulation of  Sitopaladi Pellets are disintegrate at within 15 minutes except S6, are disintegrate at within 5 minutes were observed.


Sitopaladi Churna, Binders, Disc Pelletizer, Evaluation studies of Pellets

Cite This Article

Rodagi, M. S. (2016). Formulations and Evaluations of Sitopaladi Churna Pellets by Pelletization Technique to Improve Patient Compliance, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(3), 135-144.

Recent Articles

Get FREE Updates for Upcoming
Pharma News, Jobs & Conferences

You have successfully subscribed to the newsletter

There was an error while trying to send your request. Please try again.

IJPRS will use the information you provide on this form to be in touch with you and to provide updates and marketing.