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New Contrive Protocol for Synthesis of Pyrimidine Derivatives

Received On: 26/02/2015
Accepted On: 04/03/2015


Vora, J.H., Joshi, K.A., Ram, H.K.

Author's Affiliation


Synthesis of a series of 4-(2-chloro-6-fluorophenyl)-1,2,3,4-tetrahydro-6-isopropyl-N-(substituted-phenyl)-2-thiooxopyrimidine-5-carboxamide. (4a-j) was achieved from different N-(substituted phenyl)-4-methyl-3-oxopentanamide, 2-chloro-6-fluorobenzaldehyde and thiourea using few drops of conc. hydrochloric acid added and refluxed with ethanol so to the fine yield. The structures of the products were supported by FTIR, 1H NMR and mass spectral data.


2-Chloro-6-Fluorobenzaldehyde; Hydrochloric Acid, Thiourea Only Refluxed

Cite This Article

Vora, J.H., Joshi, K.A., Ram, H.K. (2015). New Contrive Protocol for Synthesis of Pyrimidine Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 163-167.

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