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Development and Validation of Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Rosuvastatin and Diltiazem in Combined Dosage Form


Received On: 01/09/2012
Accepted On: 14/09/2012


Author(s)

Chaudhari, B. G., Patel, J.


Author's Affiliation


Abstract

A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of rosuvastatin and diltiazem in their combined dosage forms. The method was based on property of addivity of absorbances. At 295.6 rosuvastatin showed absorbance but diltiazem showed zero absorbance. The two wavelengths on rosuvastatin curve were found out where it showed same absorbance, which were 227 and 247.4 nm. Diltiazem showed adequate absorbances at these wavelengths. The method involved solving of an equation based on measurement of absorbances at three wavelengths 295.6, 227, and 247.4 nm. The proposed method was found to be simple, economical, accurate, and reproducible for routine analysis of both drugs in tablet dosage forms.


Keywords

Rosuvastatin, Deltiazem, Spectrophotometric, Dual Wavelength

Cite This Article

Chaudhari, B. G., Patel, J. (2012). Development and Validation of Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Rosuvastatin and Diltiazem in Combined Dosage Form, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 146-153.


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