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Development and Validation of First Derivative Method for Simultaneous Estimation of Rosuvastatin and Diltiazem in Combined Dosage Form


Received On: 02/09/2012
Accepted On: 22/09/2012


Author(s)

Chaudhari, B. G., Patel, J.


Author's Affiliation


Abstract

A simple and economical first derivative spectrophotometric method has been developed for the simultaneous estimation of rosuvastatin and diltiazem in their combined dosage forms. The method involved determination of Zero Crossing points (ZCP) in their respective derivative spectra. By scanning first derivative spectra of rosuvastatin and diltiazem, ZCP for rosuvastatin was found to be at 240 nm and for diltiazem at 236.4 nm. For rosuvastatin 236.4 nm and for diltiazem 240 nm was chosen as an analytical wavelength. The method involved solving of an equation based on measurement of absorbances at wavelengths 240 and 236.4 nm. The proposed method was found to be simple, economical, accurate, and reproducible for routine analysis of both drugs in tablet dosage form.


Keywords

Rosuvastatin, Deltiazem, Spectrophotometric, First Derivative

Cite This Article

Chaudhari, B. G., Patel, J. (2012). Development and Validation of First Derivative Method for Simultaneous Estimation of Rosuvastatin and Diltiazem in Combined Dosage Form, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 170-176.


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