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Development and Validation of First Derivative Spectrophotometric Method for Simultaneous Estimation of Cefixime and Moxifloxacin in Synthetic Mixture


Received On: 05/09/2012
Accepted On: 22/09/2012


Author(s)

Chaudhari, B. G., Patel, B.


Author's Affiliation


Abstract

A simple and economical first derivative spectrophotometric method has been developed for the simultaneous estimation of cefixime and moxifloxacin in their synthetic mixture. The method involved determination of Zero Crossing points (ZCP) in their respective derivative spectra. By scanning first derivative spectra of cefixime and moxifloxacin, ZCP for cefixime was found to be at 289 nm and for moxifloxacin at 316.4 nm. For cefixime 316.4 nm and for moxifloxacin 289 nm was chosen as an analytical wavelength. The method involved solving of an equation based on measurement of absorbances at wavelengths 289 and 316.4 nm. The proposed method was found to be simple, economical, accurate, and reproducible for routine analysis of both drugs in tablet dosage form.


Keywords

Cefixime, Moxifloxacin, Spectrophotometric, First Derivative

Cite This Article

Chaudhari, B. G., & Patel, B. (2012). Development and Validation of First Derivative Spectrophotometric Method for Simultaneous Estimation of Cefixime and Moxifloxacin in Synthetic Mixture, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 177-184.


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