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A Mild and Efficient Synthesis of Benzimidazole by Using Zinc Chloride under Solvent Free Condition


Received On: 13/02/2013
Accepted On: 16/02/2013


Author(s)

Tushar, M., Kaneria, D. M., Kapse, G. K., Gaikwad, T. V., Sarvaiya, J.


Author's Affiliation


Abstract

A straightforward, efficient and more sustainable solvent-free method has been developed for the synthesis of benzimidazole derivatives to achieve yields that were comparable to or better than, those in conventional media. It is noteworthy that the reaction was exclusively carried out in Zinc chloride catalysis system, rendering the methodology highly valuable from both environment and economic points of view. The various benzimidazoles were synthesized by the reaction of o-phenylenediamine with different types of aldehydes and characterized by their Physical constant, FT-IR Spectra, 1H NMR Spectra and LCMS. The excellent chemo selectivity, mild reaction condition, short reaction times and excellent yield made the best method then other methods.


Keywords

Benzimidazoles, Zinc Chloride, Solvent Free

Cite This Article

Tushar, M., Kaneria, D. M., Kapse, G. K., Gaikwad, T. V., & Sarvaiya, J. (2013). A Mild and Efficient Synthesis of Benzimidazole by Using Zinc Chloride under Solvent Free Conditio. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(1), 90-98.


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