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Development and Validation of Derivative Spectroscopic Method for the Simultaneous Estimation of Lafutidine and Rabeprazole Sodium in Combined Dosage Form


Received On: 25/02/2013
Accepted On: 28/02/2013


Author(s)

Antala, H., Raval, K., Dhudashia, K., Patel, N., Paghadar, B.


Author's Affiliation


Abstract

The Present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of Lafutidine and Rabeprazole Sodium in combined Pharmaceutical dosage form. The derivative Spectrophotometric method was based on the determination of both the drugs at their respective Zero Crossing Point (ZCP). The First order derivative spectra was obtained in Methanol and the determinations were made at 284.2nm (ZCP of Rabeprazole Sodium) for Lafutidine and 272.8nm (ZCP of Lafutidine) for Rabeprazole Sodium. The linearity was obtained in the concentration range of 10-45 μg/ml for Lafutidine and 6-20 μg/ml for Rabeprazole Sodium. The mean recovery was 102.46 ± 1.19 and 100.61 ± 1.0 for Lafutidine and Rabeprazole Sodium, respectively. The method was found to be Simple, Sensitive, Accurate and Precise as per ICH guideline Q2B(R1). The Proposed method was successfully applied for the simultaneous estimation of both the drugs in commercial Pharmaceutical dosage form.


Keywords

Lafutidine (LAF), Rabeprazole Sodium (RAB), Derivative spectrophotometry, Zero Crossing Point

Cite This Article

Antala, H., Raval, K., Dhudashia, K., Patel, N., & Paghadar, B. (2013). Development and Validation of Derivative Spectroscopic Method for the Simultaneous Estimation of Lafutidine and Rabeprazole Sodium in Combined Dosage Form. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(1), 113-120.


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