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Study of Excipients Affecting Dissolution Profile of Drug with Special Emphasis on Co Processed Excipients


Received On: 11/05/2013
Accepted On: 20/06/2013


Author(s)

Parmar, K., Vyas, J., Patel, N., Patel, R.


Author's Affiliation


Abstract

The main aim of present work is to study the impact of various excipients and co-processed excipients on dissolution rate. Direct compression is the preferred method for the preparation of tablets. Co processing is the one of the most widely explored and commercially utilized method for the preparation of directly compressible vehicle. The objective of present study is to prepare and characterize various co processed excipients and its application in tablet formulation. Co-processed excipient prepared was characterized by flow properties, solubility, Hardness, Friability, % drug content in tablet formulation. FTIR and SEM show no physical interaction between them with no chemical change. Co processing of excipients was evaluated for Drug release, mean dissolution time and dissolution efficiency Sucrose: MCC (2:1) used to extend the drug release up to 6 hr, we can prepare sustain release tablet of this CO processing by incorporation of sustain release polymer. MCC: Kyron was used to prepare immediate drug release. So based on these properties we was prepared immediate release formulation and sustain release formulation. Co-processing of Sucrose: MCC have been used to achieve sustain release by incorporation of pectin, by using this combination we can achieve sustain release up to 10 hr similarly Kyron: MCC was used in immediate release formulation. Comparison with both IR and SR marketed product and evaluated for F2 test shows there is similarity in dissolution profile between both the batches.


Keywords

Aceclofenac, Co processing, MCC: Kyron, Sucrose: MCC, Excipients

Cite This Article

Parmar, K., Vyas, J., Patel, N., Patel, R. (2013). Study of Excipients Affecting Dissolution Profile of Drug with Special Emphasis on Co Processed Excipients. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(2), 201-208.


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