IJPRS

Home Abstract

Development and Evaluation of Extended Release Formulation of Tramadol Hydrochloride Based on Osmotic Technology


Received On: 29/04/2013
Accepted On: 12/05/2013


Author(s)

Patel, J. B., Halba, P. D., Patel, K. N., Patel, P. A.


Author's Affiliation


Abstract

Extended release formulation of Tramadol Hydrochloride based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as osmotic agent, plasticizer and coating thickness of semi-permeable membrane were found to markedly affect drug release. Tramadol hydrochloride release was directly proportional to the level of osmogent and plasticizer but inversely proportional to the level of coating thickness of semi-permeable membrane. Drug release from developed formulation was independent of pH and agitation intensity but dependent on osmotic pressure of release media. The optimized formulation was compared with marketed product CONTRAMAL SR and accelerated stability study was also carried out for 6 months.


Keywords

Tramadol hydrochloride, extended release, osmotic pressure

Cite This Article

Patel, J. B., Halba, P. D., Patel, K. N., & Patel, P. A. (2013). Development and Evaluation of Extended Release Formulation of Tramadol Hydrochloride Based on Osmotic Technology. International Journal for Pharmaceutical Research Scholars (IJPRS), 2013, 2(2), 226-234.


Recent Articles

Get FREE Updates for Upcoming
Pharma News, Jobs & Conferences

You have successfully subscribed to the newsletter

There was an error while trying to send your request. Please try again.

IJPRS will use the information you provide on this form to be in touch with you and to provide updates and marketing.