IJPRS

Home Abstract

Protective Effect of Silymarin on L-Arginine Induced Acute Pancreatitis in Rats


Received On: 18/12/2013
Accepted On: 23/12/2013


Author(s)

Divya, S. K., Lakshmi, V. M., Bhanu, V., Devi, R. P., Devi, L. A.


Author's Affiliation


Abstract

Acute pancreatitis is an inflammatory disorder of the exocrine part of pancreas, which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Involvement of oxidative stress and inflammatory mediators are the major causative factors for the development of acute pancreatitis. Previous studies reported that treatment with α,β amyrin, Pentoxifylline , Alpha lipoic acid, N-acetyl cysteine, Eugenol, Allopurinol, Methyl prednisolone, Melatonin & Selenium have shown protective effect on L-Arginine induced acute pancreatitis by virtue of their anti oxidant & anti-inflammatory properties. Based on these reports, it is presumed that Silymarin, a potential antioxidant & anti-inflammatory agent which might exert a beneficial effect on L-Arginine induced acute pancreatitis in rats. Inflammation of pancreatic gland called pancreatitis (AP) may leads to sever complication and high mortality without treatment. The pathogenesis is not fully understood, however the leukocyte activation, microcirculatory disturbances and oxidative stress are the major constituents of AP. This is characterized by activation of widespread inflammatory cell infiltration, leukocyte and digestive proteases. Reactive oxygen, nitrogen species and various kinds of inflammatory mediators are released in inflammatory process. Previously it was reported that several factors are responsible for the AP, like alcohol, gallstones, hereditary pancreatitis, hypercalcemia, hyperlipidemia, malnutrition, abdominal trauma, penetrating ulcers, malignancy, drugs like steroids, sulfonamides, furosemide, thiazides, infections like mumps, Coxsackie virus, Mycoplasma pneumonia.


Keywords

Acute pancreatitis, L-arginine, Silymarin, Oxidative stress, Inflammation

Cite This Article

Divya, S. K., Lakshmi, V. M., Bhanu, V., Devi, R. P., Devi, L. A. (2013). Protective Effect of Silymarin on L-Arginine Induced Acute Pancreatitis in Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 286-299.


Recent Articles

Get FREE Updates for Upcoming
Pharma News, Jobs & Conferences

You have successfully subscribed to the newsletter

There was an error while trying to send your request. Please try again.

IJPRS will use the information you provide on this form to be in touch with you and to provide updates and marketing.