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Synthesis and Antimicrobial Studies of Schiff’s Bases of 2-Carboxy Benzaldehyde and their Azetidinone Derivatives


Received On: 22/12/2013
Accepted On: 29/12/2013


Author(s)

Prasad, A. V. G. S., Rao, P. V.


Author's Affiliation


Abstract

A series of novel Schiff’s bases of 2-carboxy benzaldehyde containing azetidinones 4(a-e) were synthesized by reaction of corresponding Schiff’s bases 3(a-e) with chloroacetyl chloride in the presence of TEA. The structures of the newly synthesized compounds 4(a-e) were established on the basis of their elemental analyses, IR, 1HNMR, 13 C NMR and mass spectral data. All the title compounds were subjected to in vitro antibacterial testing against four pathogenic strains and antifungal screening against two fungi.


Keywords

Schiff’ Base, Carboxy Benzaldehyde, Chloroacetyl Chloride, Antibacterial, Antifungal

Cite This Article

Prasad, A. V. G. S., & Rao, P. V. (2013). Synthesis and Antimicrobial Studies of Schiffs Bases of 2-Carboxy Benzaldehyde and their Azetidinone Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 386-389.


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