Abstract

Morbidity and mortality due to asthma are increasing dramatically which necessitates the development of treatment targeting the key mediators in pathogenesis of the disease. Mainly it is characterized by airway hyper responsiveness, inflammation, remodeling. Mast cells and cytokines are the major mediators in the process. Mast cell degranulation gives out many substances responsible for smooth muscle hyper responsiveness resulting in bronchoconstriction. Key event in the progression of asthma is the airway remodeling. This event encloses epithelial cell damage, subepithelial fibrosis, goblet cell hyperplasia, angiogenesis. There are also many assessment techniques like imaging, invasive, non-invasive techniques. Treatment targeting the events in airway remodeling presents the promising way for eradication of asthma.

Keywords

Asthma, Airway remodeling events, Assessment of airway remodelling, inflammatory cells

Cite This Article

Chaudhari, S. G., Chaudhari, H. R., Mishra, P. A., Shendkar, A. K., & Duvvuri, P. L. (2013). Airway Remodelling: A Key Event in Asthma. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 66-73.