Abstract

The incidence of Extended Spectrum of Beta Lactamase (ESBL) producing strains among clinical isolates has been steadily increasing with variable sensitivity rates for fluoroquinolones, aminoglycosides and 4th generation is a matter of concern. To determine the prevalence and the antibiotic susceptibility pattern of ESBL producing E.coli from various clinical samples in a tertiary care hospital, Kanchipuram, Tamilnadu. Total of 172 Escherichia coli isolates were isolated from different clinical specimens, during the period March 2012 to August 2013.They were evaluated for the presence of ESBL enzyme by combined disc diffusion test. The antibiotic sensitivity pattern of ESBL producing E.coli against various classes was determined. Out of 172 E.coli isolates 64 (37.2 %) were ESBL producers. It was found maximum in Urine sample (81.3%) and Female (67.2%) was commonly affected. More no of cases 38 (59.4%), were seen between 21-40 years 100% susceptibility was observed for imipenem, Nitrofurantoin (urine isolates), Netilmycin, Levofloxacin, and Ticarcillin/Clavulanic Acid showed 96.9%, 84.4%, 81.3% & 67.2 % sensitivity, respectively. This study highlights the prevalence of ESBL production in E.coli in our area. The quick detection is very important, because the ESBL strains can pass the gene to other clinical strains.

Keywords

E.coli, Extended Spectrum of Beta Lactamase (ESBL), antibiotic susceptibility

Cite This Article

Senthamarai, S., Sivasankari, S., Kumudhavathi, M. S., Somasunder, V. M., & Reddy, S. K. (2013). Antibiotic Susceptibility Pattern of ESBL Producing Escherichia Coli from Various Clinical Samples in a Tertiary Care Hospital, Kanchipuram, Tamilnadu. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 172-178.