Abstract

Momordica Charantia is used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of aqueous fruit extract of Momordica Charantia on alloxan induced diabetes in male albino rats. The diabetes induced animals were fed with the fruit extract at 250mg/kg body wt and 350mg/kg body wt. The aqueous fruit extract administrated animals revealed a significant (P<0.001) increment of serum insulin levels, higher reduction in hyperglycemia and hyperlipidemia when compared to the diabetic control rats (P<0.001). The histological studies of the endocrine region of pancreas of diabetic animals revealed shrinkage of ß-cells of islets of langerhans. The aqueous fruit extract treated animals revealed restoration of ß-cells.

Keywords

Momordica Charantia, Alloxan, Hyperglycemia, Hyperlipidemia

Cite This Article

Rajalakshmi, A., Senthilkumar, B., & Devi, K. (2013). Antihyperglycemic and Antihyperlipidemic Effect of Aqueous Fruit Extract of Momordica charantia against Alloxan Induced Diabetic Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 54-60.