Abstract

c-Met receptor tyrosine kinase has been under extensive basic and preclinical investigation, and is now known to be a “druggable” target with promising results of early phase clinical results of c-Met targeting agents emerging. On the basis of structure of two c-Met inhibitors, PF-04217903 and JNJ-38877605, some novel 3H-[1,2,3]triazolo[4,5-d]pyrimidines were rationally designed using the strategies of bioisosterism, synthesized and evaluated as novel c-Met inhibitors.

Keywords

c-Met inhibitor, 3H-[1, 2, 3]triazolo[4, 5-d]pyrimidines, Bioisosterism principles, Suzuki coupling reaction, Design and synthesis

Cite This Article

Lianbao, Ye., Xiaomin, Ou., Yanmei, Zhang., & Yan, Luo. (2014). Design and Synthesis of Some Novel 3H-[1, 2, 3]triazolo[4, 5-d]pyrimidines as Potential c-Met Inhibitors. International Journal for Pharmaceutical Research Scholars, 3(1), 414-421.