Abstract

The capital aim is to admix and characterize atypical thienopyrimidine derivatives and covering them for anti-inflammatory activity. An alternation of 4 substituted cyclopenta [4, 5] thieno [2, 3-d] pyrimidine (5a-5e) were synthesized from cyclopentanone. The actinic compounds, characterized on the abject of satisfactory analytic and ashen (¹H-NMR, Mass and elemental data). Studies were agitated out for the actinic compounds which were as able evaluated for anti-inflammatory activity in albino rats by appliance of a carrageenan induced paw edema method. The actinic compounds showed adequate arise that two of the compounds 5a (Ar = 4-chloro cinnamoyl) and 5e (Ar = benzyl hydrazide) showed 50% anti-inflammatory activity as compared to accustomed biologic indomethacin afterwards 2hr. All the compounds showed negligible activity afterwards 4 hr. We abode the accustomed admixture of atypical thienopyrimidine, as able as their spectral characterization, and anti-inflammatory activity which, for some, is aloft to currently acclimated as anti-inflammatory agents.

Keywords

Anti-inflammatory, Cyclopentanone, Thienopyrimidine

Cite This Article

Ahmed, O., Rahman, M. H. U., Najeeb, A., Noorullah, S. M., & Basha, S. A. A., (2013). Design, Synthesis and Anti-Inflammatory Activity of Certain Fused Novel Thienopyrimidines Derivatives. International Journal for Pharmaceutical Research Scholars, 2(4), 82-87.