Abstract

Celosia argentea Linn. is a annual shrub, commonly known as silvercock’s comb which belongs to family Amarantheceae was evaluated for its diuretic activity. The plant was extracted with 70% ethanol to obtain hydro-alcoholic extract (70:30) and concentrated to obtain residue. The toxicity study reveals that the animals show no mortality rate at highest dose level i.e; 8 gm /kg body weight which proves that C.argenta plant is non toxic. The hydro-alcoholic extract (HECA) at a dose of 400mg/kg b.w, and 600mg/kg b.w by oral route were tested for their diuretic property in swiss albino mice of either sex weighing between 18gms-30gms. A significant (*p<0.001) diuretic activity had been observed in the HECA (600mg/kg b.w) followed by HECA (400mg/kg b.w) when compared to control group. Phytochemical screening reveals the presence of alkaloids, steroids, flavonoids, tannins, triterpenoids, carbohydrates and saponins in the hydro-alcoholic extract of Celosia argentea Linn.

Keywords

Celosia Argentea Linn, Hydro-Alcoholic Extract, Diuretic, Swiss Albino Mice

Cite This Article

Kotresh, Y., Ramana, M. V., & Madhulatha, B. (2015). Diuretic Activity of Celosia Argentea Linn, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(4), 146-152.