Abstract

The therapeutic properties of plants used to cure diseases of human beings or animals dates back to earlier times of human history. Thespesia populnea belongs to malvaceae family found in coastal and tropical regions of India. The various parts of the plant including leaves, flowers, fruits, bark and root possess splendid medicinal properties such as anti-microbial, anti-oxidant, anti-inflammatory, anti-fertility, hepatoprotective, anti-steriodegenic and purgative activities. The present study is emphasized on the extraction, isolation and, characterization of phytochemical constituents exists in Thespesia populnea root system. The extracts prepared by the employment of various organic solvents such as n-hexane, methanol, ethyl acetate and water were analyzed for their antimicrobial properties against various pathogens involved in genitourinary tract infections. Amongst all the extracts, methanolic-extract exhibited significant antimicrobial activity. Furthermore, the phytochemical analysis displayed that the root system of Thespesia populnea comprises of alkaloids, terpenoids, glycosides, saponins, polysteroids and tannins. The crude methanol extract was further studied for chemical elucidaton by GC-MS technique. The prevailing compounds identified from the methanol root extracts of thespesia populnea were tetratetra acontane, octadecane, 3-ethyl-5-(2-ethylbutyl), hexadecanoic acid, methyl ester, heptadecane, 9-hexyl-, spiro[isobenzofuron-1(3H),9^′-(9H)xanthene]-3-one, 17-pentatriacontene, glycerol-1-palmitate, brequinar, astaxanthin, betulin, 7,8-epoxylanostan-11-ol, 3-acetoxy etc showed antimicrobial activity against GUTI.

Keywords

Thespesiapopulnea, Root, Extracts, Antimicrobial Property, Genitourinarytract Infections, GC-MS Analysis

Cite This Article

Lakshmi, C. S., Uma, A., Lakshminarasu, M., & Venkanna, B. (2014). Evaluation of Antimicrobial Property of Thespesia Populnea Root Extracts against Genitourinary Tract Infectious Pathogens. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 505-519.