Abstract

The objective of the present study was to develop Glibenclamide loaded nanoparticles using Chitosan as release control polymer. Different concentrations of Chitosan and Sodium Tripolyphosphate (TPP) were tried. A 3² full factorial design was used for optimization. The prepared nanoparticles were evaluated for particle size, zeta potential, % yield, and association efficiency, CPR after 1 hr and CPR after 20 hr. results obtained were subjected to regression analysis to obtain mathematical model. Using the developed model a checkpoint cum optimized formulation was developed on bases of desired characteristics and evaluated. In-vivo anti-hyperglycemic activity of the checkpoint batch was studied. The results obtained were in correlation with the predicted results. The formulation containing 0.75% w/v Chitosan and 0.4% w/v TPP was selected as optimized formulation.

Keywords

Glibenclamide, Chitosan, Nanoparticle, Factorial Design, Optimization

Cite This Article

Patel, C. J., & Patel, D. V. (2014). Formulation and Evaluation of Chitosan Nanoparticles Containing Glibenclamide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 58-68.