Abstract

The present investigation deals with the formulation and evaluation of sodium alginate and pectin based In situ gel of Cimetidine. Sodium alginate and pectin were used as a polymer and CaCO₃ was used as a cross-linking agent. In-situ forming polymeric formulations drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultra-violet irradiation, from which drug gets released in sustained and controlled manner. The objective of this study was to develop a novel in- situ gel system for sustained drug delivery using natural biodegradable polymers. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameters. In-situ gel was formed at a biological pH. In vitro release studies were conducted in simulated gastric fluid and cumulative amount of drug release was analyzed by spectrophotometry. From designed set of experiments, it was evident that formulation containing 1.2% of sodium alginate and 1.5% of pectin control the release of drug for longer duration. The in-situ gel exhibited the expected, viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability, water uptake ability and sustained drug release.The drug release from the in situ gels follows the fickian diffusion type of release.

Keywords

In-situ gel, gelation, natural biodegradable polymers, simulated gastric fluid, Cimetidine

Cite This Article

Jayswal, B.D., Yadav, V.T., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Evaluation of Floating In Situ Gel Based Gastro Retentive Drug Delivery of Cimetidine, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 327-337.