Abstract

The Glibenclamide is a drug of choice for the physician for Non Insulin Dependent Diabetes (NIDD). The drug in oral conventional dosage form has the dosage regime of three times a day. The repeated administration in a day may cause non compliance by the patients. Thus, it is emphasized to prolong/sustain release delivery of the drug to avoid repeated administration. The study comprises that floating microsphere of Glibenclamide, model drug, may increase the gastric residence time. The floating microspheres are prepared by the emulsification solvent diffusion technique using polymers Hydroxypropyl methyl cellulose, Eudragit RS100 and ethyl cellulose in different ratio 1:0, 1:1, 2:3, 1:4. The formulated microsphere was evaluated for the percentage yield, percentage encapsulation efficiency, percentage buoyancy and in vitro drug release. Floating microspheres prolong the release of the drug and gastric residence time, release almost 90% drug with in 12hrs. Thus the frequency of administration of the drug reduced to twice daily from multiple time administration.

Keywords

Floating Microsphere, Gastric Residence Time, Gastric Retention, Glibenclamide, Solvent Evaporation Diffusion method, Eudragit RS100

Cite This Article

Taneja, R., Kataria, M. K., & Bilandi, A. (2014). Formulation and Evaluation of Floating Microspheres of Glibenclamide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 48-57.