Abstract

In the present study, an attempt was made to formulate and evaluate microspheres of Eudragit S-100 for the colon targeted delivery of meloxicam for management of rheumatoid arthritis. To achieve these objectives different formulations of microspheres were prepared by emulsion solvent evaporation method by varying the polymer, surfactant as well as cross linking agent concentration. The prepared microspheres were evaluated for surface morphology, entrapment efficiency, Fourier transform infrared spectroscopy, differential scanning calorimetry and in-vitro drug release study. The obtained microspheres were spherical in shape & free flowing. The surface morphology revealed that the prepared microspheres are spherical, having smooth and dense surface. With an increase in cross linking agent, the microsphere size was decreased, whereas with increase in polymer and drug concentrations microsphere size increased. The drug entrapment efficiency of the microspheres was increased with increased in glutaraldehyde concentration. The DSC analysis indicates that there was no drug polymer interaction. The F2 formulation which shows satisfactory release in vitro was tested for its integrity. The coefficient of regression (R²) value shows drug release mechanism followed anamolous non Fickian diffusion.

Keywords

Meloxicam, Eudragit S-100, Colon Targeting, Microspheres, Cross Linking Agents

Cite This Article

Singh, N., Mittal, A., Chauhan, S., Sheikh, M., & Alam S. (2014). Formulation and Evaluation of Meloxicam Microspheres Using Eudragit S-100. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 330-339.