Abstract

The aim of our study was to improve the bioavailability of ofloxacin a practically insoluble anti-infective drug, as a model drug by using liquisolid technique. The effect of powder substrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Specifically, several liquisolid formulations, containing 200mg ofloxacin, which containing different carrier to coating ratios in their powder substrates and a fixed liquid medication, were prepared. The dissolution profiles of ofloxacin liquisolid tablets were determined according to USP method. The obtained dissolution profiles were compared to that of a commercial product. In the present study, the formulated liquisolid systems exhibited acceptable flowability and compressibility. In addition, liquisolid tablets displayed significant enhancement of the dissolution profiles compared to this of commercial one.

Keywords

Liquisolid Tablets, Ofloxacin, Formulation and Evaluation

Cite This Article

Khan, I., & Arjariya, P. (2013). Formulation and Evaluation of Ofloxacin Liquisolid Tablets. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 94-106.