Abstract

The oral delivery of lipophilic drugs presents a major challenge due to low aqueous solubility of such compounds. Atorvastatin (ATV), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is a plasma lipid-regulating agent. The chief intention of this work is to develop an orally stable self Micro-emulsifying drug delivery system by evaluating its in vitro potential. Components of SMEDDS were assessed by solubility studies on various oils, surfactants, co-surfactant. Ternary phase diagrams were constructed to identify area of micro-emulsification for the selected systems. Characterization of SMEDDS was done by Physical method, Droplet size, Zeta potential determination, drug loading capacity, Transmission test, Cloud point measurement and in vitro release study. The optimal formulation consisted of mixture of Drug (0.99%), Acrysol K150 and PEG 400 (1:1) and Gelucire 44/14 (19.80%). Droplet size of optimized batch was 87.65nm with PdI 0.493. Drug loading capacity was 2-3 times than the Actual dose of ATV. Transmission values were above 99% in pH 1.2, pH 6.8 and distilled water. Cloud point of formulations was about74°C. In vitro release inspection of optimal formulation illustrated a complete release of Atorvastatin from SMEDDS within 20 min. Our study concludes that the SMEDDS shows potential approach for the poorly water soluble drugs including Atorvastatin.

Keywords

SMEDDS, Atorvastatin, Phase titration method, Droplet size, Zeta potential

Cite This Article

Pawar, S.D., Pawar, S.P., Gujarathi, N.A., Rane, B.R. (2016). Formulation and In-vitro Evaluation of Self Micro-Emulsifying Drug Delivery System of Atorvastatin, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 333-342.