Abstract

Mouth dissolving tablets / fast dissolving tablets is gaining prominence as new drug delivery systems. These dosage forms dissolve or disintegrate in oral cavity within a matter of seconds without need of water or chewing. The present investigation of research is oriented through increasing safety and efficacy of existing drug molecule through novel concept of drug delivery. Tramadol hydrochloride is a centrally acting analgesic, which is orally and intravenously administered drug. Fast dissolving tablets of Tramadol hydrochloride were prepared by using superdisintegrants such as crospovidone, croscarmellose sodium and sodium starch glycolate in combinations and at different concentrations. The prepared batches were evaluated for organoleptic properties, hardness, friability, weight variation, in vitro dispersion time, wetting time, in vitro drug release studies and stability studies. The drug-excipients interaction was checked and found negative through Infrared spectroscopy and Differential scanning calorimetry studies. Formulation prepared by using superdisintegrants containing crospovidone 10% w/w and croscarmellose sodium 10% w/w respectively, showed minimum time for disintegrate, dispersion and drug release almost 100 % in 10 minutes. Finally it was concluded that FDTs of Tramadol hydrochloride can be successfully formulated with improved patient compliance.

Keywords

Tramadol Hydrochloride, Superdisintegrants Croscarmellose Sodium, Crospovidone, Sodium Starch Glycolate

Cite This Article

Chauhan, D., Bhitre, M., Menon, D., & Patel, N. (2014). Formulation Development and Evaluation of Fast Dissolving Tablets of Tramadol Hydrochloride. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 182-190.