Abstract

The objective of the present study was to develop colon targeted pulsatile drug delivery system of ibuprofen for the treatment of arthritis. Drug excipients interaction was carried by UV spectroscopy, FTIR, swelling index, in vitro studies by dissolution. Ibuprofen granules were prepared by wet granulation method. When different ratio used as a hit and trial method based on results obtained from initial trials (f1-f10) pulsatile capsule formulation design with hydrogel plug. The formulation evaluated for chronokinetics and in vitro studies based on physiochemical parameters and polymers ratio used. It was found that increase in the ratio of the polymer results to decrease the pulsincap properties and release of active ingredient content will also varied. Present f1 batch conducted that successfully targeted to colon in the treatment of arthritis. Drug release over the period of 5-16hr can be achieved from formaldehyde treated hard gelatine capsule and hydrogel plug.

Keywords

Pulsatile, Colon Targeted, Ibuprofen Chronokinetic, Chronotherapeutics

Cite This Article

Singh, D.N., Arora, V. (2015). In Vitro Studies for the Formulation and Evaluation of Pulsincap of Ibuprofen for Arthritis, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(3), 219-227.