Abstract

Extracts of Tinospora cordifolia viz. aqueous (TCA), hydroalcoholic (TCH), dichloromethane (TCD) extracts and guduchi satva (TCP) (starch), were studied for anti-rheumatoid activity in complete freund’s adjuvant (CFA) induced rheumatoid arthritis (RA). Female albino Wistar rats (body weight:  170 to 200 g) were divided in 11 groups each containing 3 animals. RA was induced by injecting CFA in sub plantar region of left paw in all animals (day 0) except Group I (normal control). Group II (disease group) received only CFA.  Group III (standard group) received methotrexate (0.25 mg/kg). Group IV to XI received low and high doses various extracts viz., TCA1 (50 mg/kg), TCA2 (500 mg/kg), TCH1 (10 mg/kg), TCH2 (100 mg/kg), TCD1 (10 mg/kg), TCD2 (100 mg/kg), TCP1 (500 mg/kg), TCP2 (1000 mg/kg) respectively. All the extracts and methotrexate were started on day 1 and continued till day 12 via per oral route once in a day. Phytochemical study of all the extracts was done. Body weight, volume of left paw, hemoglobin (Hb); and inflammatory markers viz. Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) and Rheumatoid Factor (RF) were measured. Higher doses of aqueous extract (500 mg/ kg), dichloromethane extract (100 mg/kg), guduchi satva (1000 mg/kg) and low dose of hydroalcoholic extract (10 mg/kg) showed better improvement in paw volume and reduced inflammatory markers as well as improved hemoglobin level.  All the Tinospora cordifolia extracts showed antiarthritic and antirheumatoid activity. Tinospora cordifolia extracts reduced inflammation and improved RA associated anemia.

Keywords

Tinospora cordifolia, Rheumatoid Arthritis, Complete Freund’s Adjuvant, Methotrexate, Guduchi Satva

Cite This Article

Shah, P.A., Shah, G.B. (2016). Preliminary Screening of Tinospora cordifolia Extracts and Guduchi Satva for Anti-Rheumatoid Activity, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 7-13.