Abstract

The aim of present study was to prepare nanosuspensions of Olmesartan medoxomil (OM), an antihypertensive drug with low water solubility, by the emulsion-diffusion technique using three different stabilizers like Pluronic F-68, Polyvinylpyrolidone K-30 (PVP K-30)  and Sodium lauryl sulphate (SLS) with the help of ultrasound. Formulations were characterized by particle size analysis, zeta potential determination (ZP), Diffuse reflectance infrared fourier transform spectroscopy (DRIFT), powder  X-ray diffraction (PXRD), scanning electron microscopy imaging (SEM), saturation solubility, dissolution testing and stability studies. Optimization of the technological parameters (organic solvents, stabilizers, sonication procedure and recovery of particles) allowed the formation of nanosuspensions with a particle size of 50-500 nm. SEM imaging confirmed the nanosized drug particles and particle morphology was influenced by choice of stabilizers. DRIFT studies indicate absence of hydrogen bonding between drug, stabilizer and lyoprotectant. PXRD patterns of the formulation revealed crystalline nature of drug particles was reduced as a result of nanoprecipitation, ultrasonication and lyophilization. Both nanosuspensions and freeze dried nano-sized powders of olmesartan medoxomil showed a dramatic increase of dissolution rate and extent compared to pure drug.  Prepared nanosuspensions and freeze dried powders were found to be stable for the period of 3 months at room temperature, accelerated stability conditions and refrigeration conditions.

Keywords

Olmesartan Medoxomil, Nanosuspensions, Dissolution, Freeze Drying

Cite This Article

Kamble, K. K., & Mahadik, K. R. (2014). Preparation & Characterization of Olmesartan Medoxomil Nanosuspensions Prepared By Emulsion Diffusion Technique. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 102-112.