Abstract

Cobalt(II),Nickel(II),Copper(II) and Manganese(II) complexes having the general composition [M(L)(X)]X (where M=Co, Ni, Cu and Mn and X=Cl) have been synthesized from 2,6-pyridinedicarboxylicacid, 4-amino acetophenone and o-phenylene diamine. The structure of the complexes was characterized by elemental analysis, conductivity measurements, magnetic moment, IR, UV-Vis, electrochemical and ESR spectral studies. Molar conductance measurements revealed that the complexes are electrolytic in nature. The redox behavior of the complexes was explained by cyclic voltammetry.  The IR spectra of all metal complexes indicate that the ligands coordinates to the metal ions through four azomethine nitrogen atoms and one pyridyl nitrogen atoms and also show the coordination of one chlorine atom. The magnetic moment values and electronic spectral data suggest an octahedral geometry for all the complexes. The Schiff base and their complexes have been screened for their in-vitro antibacterial and antifungal activities against different species of pathogenic bacteria and fungi. The DNA cleavage study was done by agarose gel electrophoresis technique on CT- DNA.

Keywords

Antimicrobial, Macrocyclic complexes, 2,6-pyridinedicarboxylicacid, DNA cleavage

Cite This Article

Malathy, M., & Rajavel, R. (2014). Preparation, Spectral Characterization, Antimicrobial and DNA Cleavage Studies of Macrocyclic Metal (II) Complexes. International Journal for Pharmaceutical Research Scholars, 3(1), 251-263.