Abstract

Improving oral bioavailability of drugs remains most challenging aspects in formulation development due to solubility problems of poorly water soluble drugs. Most of the new chemical entities (NCEs) are poorly water soluble as well as not well-absorbed after oral administration. Solid dispersion technologies are promising task for improving solubility and hence oral bioavailability of Biopharmaceutical Classification System (BCS) class II drugs. Solid dispersion techniques have attracted due to improving the dissolution rate of highly lipophilic drugs and hence their bioavailability. This article reviews on classification, various preparation methods, advantages and disadvantages of solid dispersion.

Keywords

Solubility enhancement, Bioavailability Enhancement, Biopharmaceutical Classification, Carrier, Poorly water soluble drug

Cite This Article

Bhut, V.Z., Prajapati, A.B., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Solid Dispersion As A Strategy To Enhance Solubility: A Review Article, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 490-498.